What is poloxamer made of?
What is poloxamer made of?
Poloxamer is an amphiphilic block copolymer, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethyelene oxide) triblock copolymer (PEO-PPO-PEO) as shown in Figure 32.
What is polyoxyethylene polyoxypropylene block copolymer?
Polyoxyethylene-polyoxypropylene surface-active block copolymers (Pluronic®) were evaluated as a vehicle for subcutaneous administration of drugs using a phenolsulfophthalein (PR) as a tracer. The results obtained suggest that PF127 aqueous gels may be of practical use as a vehicle for SC administration of drugs.
What is poloxamer used for?
What is it? Poloxamers are polymers used for drug delivery as formulation excipients. They are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. They are also used in topical dosage forms and rectal suppositories.
What is a poloxamer gel?
Poloxamers are thermo-responsive polymers that are widely used in the development of in situ gel systems. These polymers are ABA-type triblock copolymers that are composed of polyoxyethylene (A) and polyoxypropylene (B) units.
Is poloxamer 188 a surfactant?
Poloxamer 188 is a synthetic surfactant that is a multiblock copolymer.
Is poloxamer water soluble?
Poloxamers, available also under the trademark Pluronics® (BASF), are a class of water-soluble nonionic A-B-A and B-A-B triblock copolymers, where A is poly(ethylene oxide) (PEO) and B is poly(propylene oxide) (PPO).
Is poloxamer water-soluble?
Is poloxamer 188 toxic?
In humans, the plasma concentration of Poloxamer 188 (given intravenously) reached a maximum at 1 h, then reached a steady state. Poloxamers can cause hypercholesterolemia and hypertriglyceridemia in animals, but overall, they are relatively nontoxic to animals, with LD(50) values reported from 5 to 34.6 g/kg.
Is poloxamer a surfactant 407?
Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature.
What is the molecular weight of poloxamer 407?
approximately 12.6 kDa
The formal molecular weight of poloxamer 407 is approximately 12.6 kDa with the lengths of two PEO blocks of 101 repeat units and a PPO block of 56 repeat units [2, 4].
Is poloxamer safe for eyes?
Poloxamers were minimal ocular irritants, but were not dermal irritants or sensitizers. A test in bacteria did not identify any mutagenic activity of Poloxamer 407. Several studies suggested anti-carcinogenic effects of Poloxamers.
Is poloxamer 407 ionic or covalent?
What are the names of the poloxamer polymer blocks?
Poloxamers are also known by the trade names Pluronic, Kolliphor (pharma grade), and Synperonic. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties.
How is the poloxamer P123 used in Materials Science?
In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15. When mixed with water, concentrated solutions of poloxamers can form hydrogels. These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.
Who is the inventor of the poloxamer copolymer?
Poloxamer. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). The word poloxamer was coined by the inventor, Irving Schmolka, who received the patent for these materials in 1973.
Which is the hydrophobic chain in a poloxamer?
Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)).