What is apolipoprotein A1 Milano?

ApoA1-M (apolipoprotein A1-Milano) is a mutant form of human apoA1 which is the major convecting protein of the HDL macromolecule. ApoA1-M is formed as a result of arginine 173 to cysteine substitution, conferring antithrombotic effects, and protection from cardiovascular diseases.

What is the A1 Milano gene?

Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 protein found in human HDL, the lipoprotein particle that carries cholesterol from tissues to the liver and is associated with protection against cardiovascular disease.

Is apolipoprotein AI Milano harmful?

Despite a lipid profile that is usually associated with a high risk of premature cardiovascular disease, apoA-IM carriers display no increase in cardiovascular disease or events (10, 14, 15).

What is Apo A1 in blood test?

An Apo A1 blood test measures the A1 protein that has a specific role in the metabolism of lipids and is the main protein component in HDL, the “good cholesterol”.

Is apolipoprotein AI Milano good?

The mutant apolipoprotein A-I(Milano) has been associated with a reduced incidence of coronary disease in carriers. Furthermore, recombinant apolipoprotein A-I(Milano) has displayed remarkable atheroprotective activities and the possibility of directly reducing the burden of atherosclerosis in experimental models.

What is Apo A?

Apolipoprotein A is a protein carried in HDL (“good”) cholesterol. It helps start the process for HDL to remove bad types of cholesterol from your body. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.

What causes low Apo A?

Your apolipoprotein A levels may be low if you have: Low levels of apolipoprotein (familial hypoalphalipoproteinemia) Tangier disease, a rare inherited disorder that lowers the amount of HDL. Hepatocellular disorders, which are certain types of liver problems.