How does nanoparticle drug delivery work?

Perhaps the most publicized use of nanotechnology in drug delivery under development is the use of nanoparticles to deliver drugs to cancer cells. Particles are engineered so that they are attracted to diseased cells, which allows direct treatment of those cells.

What are new drug delivery methods?

Drug delivery systems (DDSs) are developed to deliver the required amount of drugs effectively to appropriate target sites and to maintain the desired drug levels. Research in newer DDS is being carried out in liposomes, nanoparticles, niosomes, transdermal drug delivery, implants, microencapsulation, and polymers.

How is targeted drug delivery done?

Targeted drug delivery is a type of drug delivery system in which the medication is transported or concentrated selectively at the site of action to localize the interaction of drug with diseased site and to avoid the harmful effects to healthy tissue due to drug interactions.

What is the main advantage of using nanotechnology for drug delivery?

Applying nanotechnology to drug delivery should achieve the following benefits: Improve the ability to deliver drugs that are poorly water soluble. Provide site-specific targeting to reduce drug accumulation within healthy tissue. Help retain the drug in the body long enough for effective treatment.

What is a nanoparticle used for?

Nanoparticles are now being used in the manufacture of scratchproof eyeglasses, crack- resistant paints, anti-graffiti coatings for walls, transparent sunscreens, stain-repellent fabrics, self-cleaning windows and ceramic coatings for solar cells.

What are advantages of nanoparticles?

The important technological advantages of nanoparticles used as drug carriers are high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral application and inhalation.

What is novel drug delivery method?

Novel Drug delivery System (NDDS) refers to the approaches, formulations, technologies, and systems for transporting a pharmaceutical compound in the body as needed to safely achieve its desired therapeutic effects. NDDS is a system for delivery of drug other than conventional drug delivery system.

Why targeted drug delivery is important?

The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug side-effects, and reduced fluctuation in circulating drug levels.

What are the advantages and disadvantages of targeted drug delivery?

Advantages: Convenience in Administration, Non invasive, accurate dose, Higher compliance, Economical [8 – 10]. Disadvantages: Unconscious patients cannot take dose, Low solubility and permeability, Degradation by Gastro Intestinal flora, first pass metabolism, Food interactions, and Poor bioavailability.

How is laponite used in the healthcare industry?

Aside from these two major uses, Laponite has been used in the healthcare industry as a bioink additive to hydrogels, enabling a habitable environment for stem cells and also playing a role in creating a biodegradable containment for drug delivery.

What kind of degradation can laponite be subjected to?

Laponite® has been shown to degrade, particularly under acidic conditions, resulting in the release of degradation products such as aqueous silica (Si (OH)4), sodium, magnesium and lithium ions into the medium.15 More recently, the vulnerability of Laponite® to chemical degradation was further investigated.

What is the chemical structure of a laponite?

Schematic representation of the Laponite® nanocrystal geometry (disk shape) and chemical structure. The circular surfaces of the crystal possess a negative charge due to substitution of Mg2+ by Li + in the octahedral layer of the crystal.

What happens to the viscosity of a laponite bioink?

Laponite bioink has been proven to decrease in viscosity when force is applied allowing an easy process when creating various layers. After the layers are created, Laponite is able to regain its viscosity and retain the shape of the desired form.