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What is the context-sensitive half-life of propofol?

What is the context-sensitive half-life of propofol?

Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion.

How long does it take for propofol to reach steady state?

Despite the very long elimination half-life, blood propofol concentrations appeared to approach steady state within 20 min rather than the 4-5 half-lives normally expected.

When should propofol not be used?

In some cases, you may not be able to use propofol. The FDA cautions recommends against using propofol if you are allergic to eggs, egg products, soybeans, or soy products.

Why does propofol have a high volume of distribution?

Administration and Absorption Propofol has zero oral bioavailability; and in any case it is very bitter-tasting. It is invariably given intravenously. Propofol is 98% protein bound. Thus, it has the highest volume of distribution of any induction agent.

What is the meaning of context sensitive?

context-sensitiveadjective. Sensitive to context; exhibiting different behaviour depending on a task or situation. Right-click anywhere in the document window, and a context-sensitive menu appears.

Why is propofol so short acting?

The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.

What is the context sensitive half-life of remifentanil?

The context sensitive half-life for remifentanil is 3.2 minutes and is independent of the duration of the infusion conversely to all other u-agonists [3]. In comparison, after a 3-hour infusion of alfentanil, the context-sensitive half-life was found to be 47.3 minutes.

What causes propofol to burn?

The pain is due to irritation of venous adventitia leading to release of mediators such as kininogen from kinin cascade. Lignocaine and ketamine are the most commonly used drugs to alleviate POPI.

What are the long-term side effects of propofol?

Conclusion: The limited data available suggest that long-term infusion of propofol is a practical alternative to use of standard agents for sedation of intubated patients. Adverse effects such as cardiovascular depression, respiratory depression, and hypertriglyceridemia may limit the routine use of propofol.

Why is thiopental short acting?

As with all lipid-soluble anaesthetic drugs, the short duration of action of sodium thiopental is due almost entirely to its redistribution away from central circulation into muscle and fatty tissue, due to its very high lipid–water partition coefficient (approximately 10), leading to sequestration in fatty tissue.

Why does propofol turn urine green?

Propofol is mainly metabolized and conjugated in the liver and excreted in urine predominantly as 1- glucuronide, 4-glucuronide, and 4-sulfate conjugates of 2,6-diisopropyl-1,4 quinol. The green colour of urine is believed to be attributed to the presence of these phenolic metabolites [4–11].