What drugs are Nitroimidazoles?

What Are Names of Nitroimidazoles Drugs?

• Flagyl.
• Flagyl ER.
• Flagyl IV RTU.
• Metronidazole.
• Secnidazole.
• Solosec.
• Tindamax.
• Tinidazole.

What is called Mycobacterium tuberculosis?

Tuberculosis (TB) is caused by a bacterium called Mycobacterium tuberculosis. The bacteria usually attack the lungs, but TB bacteria can attack any part of the body such as the kidney, spine, and brain. Not everyone infected with TB bacteria becomes sick.

Which of the following is a nitroimidazole?

Metronidazole and Nitrofuran Metronidazole is a nitroimidazole antibiotic used primarily against anaerobic bacteria (e.g., Clostridium difficile), some microaerophilic bacteria (Helicobacter pylori and Gardnerella vaginalis), and protozoan infections.

What is nitroimidazole drug family?

Nitroimidazole antibiotics Drugs of the 5-nitro variety include metronidazole, tinidazole, nimorazole, dimetridazole, pretomanid, ornidazole, megazol, and azanidazole. Drugs based on 2-nitromidazoles include benznidazole. Nitroimidazole antibiotics have been used to combat anaerobic bacterial and parasitic infections.

What is the target for clavulanic acid?

Clavulanic acid contains a beta-lactam ring and binds strongly to beta-lactamase at or near its active site, thereby hindering enzymatic activity. This protects other beta-lactam antibiotics from beta-lactamase catalysis, thereby enhancing their antibacterial effects.

Which antibiotic is bactericidal?

Bactericidal antibiotics that inhibit cell wall synthesis: the beta-lactam antibiotics (penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems) and vancomycin. Also bactericidal are daptomycin, fluoroquinolones, metronidazole, nitrofurantoin, co-trimoxazole, telithromycin.

How is tuberculosis defined?

Tuberculosis (TB) is a contagious infection that usually attacks your lungs. It can also spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it.

What are Nitroimidazoles used for?

Nitroimidazole antibiotics are used to treat parasitic infections, amoebiasis, bacterial vaginosis, gastrointestinal infections, skin infections, meningitis, lower respiratory infections, bacterial infections, diarrhea, and rosacea.

What are the derivatives of nitroimidazole?

5 Nitroimidazole Derivative

• In Vitro.
• Azathioprine.
• Tinidazole.
• Fexinidazole.
• Metronidazole.
• Host Resistance.
• Hydroxyl Group.
• Alkyl Group.

Is metronidazole the same as nitroimidazole?

Metronidazole belongs to the nitroimidazole class of antibiotics and is active against protozoa in addition to anaerobic bacteria. It is bactericidal to anaerobic organisms through formation of free radicals that inhibit DNA synthesis and cause DNA degradation.

What is nitroimidazole derivative?

Nitroimidazoles are used to treat bacterial vaginosis (frequently associated with G. vaginalis) and dental infections, including acute necrotizing ulcerative gingivitis (Vincent’s angina).

Why is nitroimidazole important for the treatment of TB?

The nitroimidazole class holds great potential for addressing several key issues in TB therapy. For the reasons stated earlier, these agents could have a major impact on TB treatment by shortening therapy, and safely and efficaciously treating both MDR-TB and HIV–TB co-infections.

What is the mechanism of action of nitroimidazole?

Metronidazole is a nitroimidazole antimicrobial with activity against protozoa and anaerobic bacteria but no activity against other bacteria. The mechanism of action involves the reduction of the nitro group on the antibiotic by nitroreductases produced by susceptible bacteria.

How often can you take nitroimidazole for cats?

A nitroimidazole drug, ronidazole, is the drug of choice for the treatment of T. blagburni in cats. 19 The dosage is 30 mg/kg orally (PO) once a day for 14 consecutive days.

What are the side effects of nitroimidazole in dogs?

The main adverse effect of treatment in dogs is vomiting. In human patients, it can cause skin rashes, peripheral neuropathy, and less commonly bone marrow suppression. It also has the potential to be carcinogenic.